Neurology Newsfeed
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Psychological issues in the evaluation and treatment of tension-type headache
Rosen NL et al. - Tension-type headache (TTH) is a common disease that is usually minimally impairing. However, more chronic TTH can be associated with significant disability and psychological comorbi...Mon, 05 Jan 2009 00:00:00 EST
Advances in the pharmacologic treatment of tension-type headache
Bigal ME et al. - For preventive treatment, amitriptyline is the best-studied drug, but nortriptyline, mirtazapine, tizanidine, the selective serotonin reuptake inhibitors, and other medications can b...Mon, 05 Jan 2009 00:00:00 EST
New Migraine Drug Shows Promise
A drug called telcagepant proved safe and effective in treating migraines and caused fewer side effects than the widely-used migraine drug zolmitriptan (Zomig), according to a study.......Wed, 31 Dec 2008 00:00:00 EST
Diagnostic issues in tension-type headache
Sacco S et al. - The diagnosis of tension-type headache (TTH) is divided into two categories: episodic TTH and chronic TTH. It is important to differentiate TTH from other headaches, in...Tue, 30 Dec 2008 00:00:00 EST
Could glial activation be a factor in migraine
Bartley J - The focus on neuronal function has ignored the potential contribution of glial cell activation to neural hypersensitivity and pain. If the central neuronal hypersensitivity ...Tue, 30 Dec 2008 00:00:00 EST
Decision making in patients with temporal lobe epilepsy
Labudda K et al. - The results demonstrate for the first time that presurgical patients with TLE can have selective reductions in decision making and that these deficits can result from...Mon, 05 Jan 2009 00:00:00 EST
Utility of Lumbar Puncture for First Simple Febrile Seizure Among Children 6 to 18 Months of Age
Kimia AA et al. - The risk of bacterial meningitis presenting as first simple febrile seizure at ages 6 to 18 months is very low. Current American Academy of Pediatrics recommendations ...Mon, 05 Jan 2009 00:00:00 EST
Seizures and Status Epilepticus in the Intensive Care Unit
Ziai WC et al. - The review takes the perspective of the neurological consultant in the intensive care unit, and considers all pharmacological approaches available to the intensivist as...Wed, 31 Dec 2008 00:00:00 EST
Clinical features and immunohistochemical changes of pituitary apoplexy
Mou C et al. - Clinical manifestations included headaches, vision loss, pituitary function change, visual field defects, and nausea and vomiting. Male patients and patients with functio...Mon, 05 Jan 2009 00:00:00 EST
Molecular analysis of novel PROP1 mutations associated with combined pituitary hormone deficiency (CPHD)
Kelberman D et al. - Mutations in PROP1 are a frequent cause of familial CPHD. Authors have described four novel mutations in PROP1 in 3 pedigrees, all resulting in PROP1 deficiency by ...Mon, 05 Jan 2009 00:00:00 EST
Effects of aromatase inhibition in hypogonadal older men: a randomized, double-blind, placebo-controlled trial
Burnett-Bowie SA et al. - Mnastrozole administration normalized androgen production in older hypogonadal men and decreased E2 production modestly. These alterations did not improve body...Mon, 05 Jan 2009 00:00:00 EST
Alzheimer disease: Time to improve its diagnosis and treatment
Salloway S et al. - Some of its risk factors may be modifiable, and although current drugs offer only modest benefit, true disease-modifying drugs are on the horizon. This review is aim...Mon, 05 Jan 2009 00:00:00 EST
A Syndrome with Congenital Neutropenia and Mutations in G6PC3
Boztug K et al. - Defective function of glucose-6-phosphatase, catalytic subunit 3, underlies a severe congenital neutropenia syndrome associated with cardiac and urogenital malformations.......Mon, 05 Jan 2009 00:00:00 EST
Illness perceptions in patients with fibromyalgia
van Ittersum MW et al. - This study confirmed that the IPQ-R English language version can be adapted and used in a sample of fibromyalgia patients. The Dutch language version for fibromyalgia...Mon, 05 Jan 2009 00:00:00 EST
Aneurysmal Subarachnoid Hemorrhage in a Mexican Multicenter Registry of Cerebrovascular Disease: The RENAMEVASC Study
Ruiz-Sandoval JL et al. - Hypertension is the main risk factor for aneurysmal SAH in hospitalized patients from Mexico. The female:male ratio is 2:1. A relatively low in-hospital mortality an...Mon, 05 Jan 2009 00:00:00 EST
Percent Change on the National Institutes of Health Stroke Scale: A Useful Acute Stroke Outcome Measure
Bruno A et al. - This novel approach to the NIHSS score as an outcome measure in acute stroke appears to be an additional useful analytic and communication tool.......Mon, 05 Jan 2009 00:00:00 EST
Dispensing errors have been reported between TOPAMAX® (topiramate) Tablets and TOPROL-XL® (metoprolol succinate) extended-release Tablets.
Please be sure to check your tablets to ensure you are taking the right medicine.
*TOPROL-XL is a registered trademark of the AstraZeneca group of companies.
TOPAMAX Tablets and TOPAMAX Sprinkle Capsules are indicated for adults for the prophylaxis of migraine headache. The usefulness of TOPAMAX in the acute treatment of migraine headache has not been studied.
TOPAMAX is contraindicated in patients with a history of hypersensitivity to any component of this product.
IMPORTANT SAFETY INFORMATION
TOPAMAX has been associated with serious adverse events, including:
- Hyperchloremic, non-anion gap metabolic acidosis - lowering of bicarbonate levels in the blood. Measurement of baseline and periodic serum bicarbonate is recommended.
- Acute myopia and secondary angle-closure glaucoma - patients should be cautioned to seek medical attention if they experience blurred vision or ocular pain.
- Oligohidrosis and hyperthermia - decreased sweating and increased body temperature, especially in hot weather. The majority of reports have been in children.
- Cognitive/psychiatric side effects including cognitive dysfunction, psychiatric/behavioral disturbances, including suicidal thoughts or behavior, and somnolence and fatigue.
Most common adverse events associated with TOPAMAX 100 mg vs placebo were: paresthesia, 51% vs 6%; anorexia,* 15% vs 6%; fatigue, 15% vs 11%; nausea, 13% vs 8%; diarrhea, 11% vs 4%; weight decrease, 9% vs 1%; taste alteration, 8% vs 1%.
The possibility of decreased contraceptive efficacy and increased breakthrough bleeding should be considered in patients taking combination oral contraceptive products with TOPAMAX.
Patients should be instructed to maintain an adequate fluid intake in order to minimize the risk of renal stone formation.
*Anorexia is defined as loss of appetite
Please see full U.S. Prescribing Information
